Klozapin

Klozapin bir psikiyatrik ilaçtır ve ilk atipik antipsikotiktir.^[1] Şizofreni ve şizoaffektif bozukluklar dahil olmak üzere belirli ruh hali veya zihinsel bozuklukları tedavi etmek için kullanılır. Türkiye'de Clonex ismiyle satılır.

Klozapin, diğer antipsikotiklere yetersiz yanıt veren ekstrapiramidal yan etkiler nedeniyle diğer ilaçları tolere edemeyen şizofreni tanılı kişiler için genellikle tablet veya sıvı formda kullanılır. Parkinson hastalığında psikoz tedavisinde de kullanılır.^[2]^[3] Klozapin, diğer ilaçlar yeterince etkili olmadığında altın standart tedavi olarak kabul edilir ve kullanımı birçok uluslararası tedavi kılavuzu tarafından tavsiye edilir.^[4]^[5]^[6]^[7]^[8]^[9]^[10]

Kaynakça

^ The clozapine handbook. 16 Mayıs 2019. ISBN 978-1-108-44746-1. OCLC 1222779588.
^ "Clozaril 25 mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. 14 Eylül 2021 tarihinde kaynağından arşivlendi. Erişim tarihi: 14 Eylül 2021.
^ Parkinson's disease in adults : diagnosis and management : full guideline. OCLC 1105250833.
^ "World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance". The World Journal of Biological Psychiatry. 13 (5): 318-78. July 2012. doi:10.3109/15622975.2012.696143. PMID 22834451.
^ "The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements". Schizophrenia Bulletin. 36 (1): 71-93. January 2010. doi:10.1093/schbul/sbp116. PMC 2800144 . PMID 19955390.
^ "Schizophrenia practice guidelines: international survey and comparison". The British Journal of Psychiatry. 187 (3): 248-55. September 2005. doi:10.1192/bjp.187.3.248. PMID 16135862.
^ "Management of psychosis and schizophrenia in adults: summary of updated NICE guidance". BMJ. 348: g1173. February 2014. doi:10.1136/bmj.g1173. PMID 24523363. 24 Ocak 2021 tarihinde kaynağından arşivlendi17 Ekim 2021.
^ "Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology". The American Journal of Psychiatry. 174 (3): 216-229. March 2017. doi:10.1176/appi.ajp.2016.16050503. PMC 6231547 . PMID 27919182.
^ "Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders". The Australian and New Zealand Journal of Psychiatry. 50 (5): 410-72. May 2016. doi:10.1177/0004867416641195. PMID 27106681.
^ "Guidelines for the Pharmacotherapy of Schizophrenia in Adults". Canadian Journal of Psychiatry. 62 (9): 604-616. September 2017. doi:10.1177/0706743717720448. PMC 5593252 . PMID 28703015.

[1] The clozapine handbook. 16 Mayıs 2019. ISBN 978-1-108-44746-1. OCLC 1222779588.

[medicines.org.uk-2] "Clozaril 25 mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. 14 Eylül 2021 tarihinde kaynağından arşivlendi. Erişim tarihi: 14 Eylül 2021.

[:1-3] Parkinson's disease in adults : diagnosis and management : full guideline. OCLC 1105250833.

[:2-4] "World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance". The World Journal of Biological Psychiatry. 13 (5): 318-78. July 2012. doi:10.3109/15622975.2012.696143. PMID 22834451.

[:3-5] "The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements". Schizophrenia Bulletin. 36 (1): 71-93. January 2010. doi:10.1093/schbul/sbp116. PMC 2800144 . PMID 19955390.

[:4-6] "Schizophrenia practice guidelines: international survey and comparison". The British Journal of Psychiatry. 187 (3): 248-55. September 2005. doi:10.1192/bjp.187.3.248. PMID 16135862.

[:5-7] "Management of psychosis and schizophrenia in adults: summary of updated NICE guidance". BMJ. 348: g1173. February 2014. doi:10.1136/bmj.g1173. PMID 24523363. 24 Ocak 2021 tarihinde kaynağından arşivlendi17 Ekim 2021.

[:6-8] "Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology". The American Journal of Psychiatry. 174 (3): 216-229. March 2017. doi:10.1176/appi.ajp.2016.16050503. PMC 6231547 . PMID 27919182.

[:7-9] "Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders". The Australian and New Zealand Journal of Psychiatry. 50 (5): 410-72. May 2016. doi:10.1177/0004867416641195. PMID 27106681.

[10] "Guidelines for the Pharmacotherapy of Schizophrenia in Adults". Canadian Journal of Psychiatry. 62 (9): 604-616. September 2017. doi:10.1177/0706743717720448. PMC 5593252 . PMID 28703015.

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