DAZ2

DAZ2
Tanımlayıcılar
Başka adlar	DAZ2
Dış kimlikler	OMIM: 400026 MGI: 1342328 HomoloGene: 86954 GeneCards: DAZ2
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• RNA binding; • nucleic acid binding; • translation activator activity; • GO:0001948, GO:0016582 protein bağlanması; • mRNA binding; • mRNA 3'-UTR binding;
Hücresel bileşeni	• hücre çekirdeği; • sitoplazma; • intracellular anatomical structure; • GO:0009327 protein-containing complex;
Biyolojik süreci	• multicellular organism development; • hücresel farklılaşma; • Spermatogenez; • single fertilization; • positive regulation of translational initiation; • 3'-UTR-mediated mRNA stabilization; • germ cell development;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	57055
	13164
	ENSG00000205944
	ENSMUSG00000010592
	Q13117
	Q64368
	NM_020363; NM_001005785; NM_001005786
	NM_001277863; NM_010021
	NP_001005785; NP_001005786; NP_065096
	NP_001264792; NP_034151
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

DAZ2, insan Y kromozomunda yer alan DAZ2 geni tarafından kodlanan bir proteindir.^[3]^[4]

Kaynakça

^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saxena R, de Vries JW, Repping S, Alagappan RK, Skaletsky H, Brown LG, Ma P, Chen E, Hoovers JM, Page DC (Sep 2000). "Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome". Genomics. 67 (3). ss. 256-67. doi:10.1006/geno.2000.6260. PMID 10936047.
^ "Entrez Gene: DAZ2 deleted in azoospermia 2". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

Ek okuma

Foresta C, Ferlin A, Moro E, ve diğerleri. (2002). "[Microdeletion of chromosome Y in male infertility: role of the DAZ gene]". Ann. Ital. Med. Int. 16 (2). ss. 82-92. PMID 11688365.
Fox MS, Reijo Pera RA (2002). "Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair". Mol. Cell. Endocrinol. 184 (1–2). ss. 41-9. doi:10.1016/S0303-7207(01)00646-3. PMID 11694340.
Vogt PH, Fernandes S (2003). "Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?". APMIS. 111 (1). ss. 115-26; discussion 126-7. doi:10.1034/j.1600-0463.2003.11101161.x. PMID 12752250.
Reijo R, Lee TY, Salo P, ve diğerleri. (1995). "Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene". Nat. Genet. 10 (4). ss. 383-93. doi:10.1038/ng0895-383. PMID 7670487.
Saxena R, Brown LG, Hawkins T, ve diğerleri. (1996). "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned". Nat. Genet. 14 (3). ss. 292-9. doi:10.1038/ng1196-292. PMID 8896558.
Yen PH, Chai NN, Salido EC (1997). "The human autosomal gene DAZLA: testis specificity and a candidate for male infertility". Hum. Mol. Genet. 5 (12). ss. 2013-7. doi:10.1093/hmg/5.12.2013. PMID 8968756.
Yen PH, Chai NN, Salido EC (1997). "The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions". Mamm. Genome. 8 (10). ss. 756-9. doi:10.1007/s003359900560. PMID 9321470.
Habermann B, Mi HF, Edelmann A, ve diğerleri. (1998). "DAZ (Deleted in AZoospermia) genes encode proteins located in human late spermatids and in sperm tails". Hum. Reprod. 13 (2). ss. 363-9. doi:10.1093/humrep/13.2.363. PMID 9557839.
Agulnik AI, Zharkikh A, Boettger-Tong H, ve diğerleri. (1998). "Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations". Hum. Mol. Genet. 7 (9). ss. 1371-7. doi:10.1093/hmg/7.9.1371. PMID 9700189.
Tsui S, Dai T, Roettger S, ve diğerleri. (2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3). ss. 266-73. doi:10.1006/geno.2000.6169. PMID 10857750.
Ruggiu M, Cooke HJ (2000). "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein". Gene. 252 (1–2). ss. 119-26. doi:10.1016/S0378-1119(00)00219-5. PMID 10903443.
Reijo RA, Dorfman DM, Slee R, ve diğerleri. (2000). "DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice". Biol. Reprod. 63 (5). ss. 1490-6. doi:10.1095/biolreprod63.5.1490. PMID 11058556.
Moro E, Ferlin A, Yen PH, ve diğerleri. (2000). "Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome". J. Clin. Endocrinol. Metab. 85 (11). ss. 4069-73. doi:10.1210/jcem.85.11.6929. PMID 11095434.
Xu EY, Moore FL, Pera RA (2001). "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans". Proc. Natl. Acad. Sci. U.S.A. 98 (13). ss. 7414-9. Bibcode:2001PNAS...98.7414Y. doi:10.1073/pnas.131090498. PMC 34683 . PMID 11390979.
Friel A, Houghton JA, Glennon M, ve diğerleri. (2002). "A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men". Int. J. Androl. 25 (1). ss. 59-64. doi:10.1046/j.1365-2605.2002.00326.x. PMID 11869379.
Fernandes S, Huellen K, Goncalves J, ve diğerleri. (2002). "High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia". Mol. Hum. Reprod. 8 (3). ss. 286-98. doi:10.1093/molehr/8.3.286. PMID 11870237.
Ferlin A, Moro E, Rossi A, Foresta C (2002). "A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men". J. Endocrinol. Invest. 25 (1). ss. RC1-3. doi:10.1007/bf03343952. PMID 11883873.

[1] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10936047-3] Saxena R, de Vries JW, Repping S, Alagappan RK, Skaletsky H, Brown LG, Ma P, Chen E, Hoovers JM, Page DC (Sep 2000). "Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome". Genomics. 67 (3). ss. 256-67. doi:10.1006/geno.2000.6260. PMID 10936047.

[entrez-4] "Entrez Gene: DAZ2 deleted in azoospermia 2". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

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