AASDHPPT

AASDHPPT
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	2BYD, 2C43, 2CG5
Tanımlayıcılar
Başka adlar	AASDHPPT, AASD-PPT, LYS2, LYS5, CGI-80, aminoadipat semialdehit dehidrojenaz-fosfopanteteinil transferaz
Dış kimlikler	OMIM: 607756 MGI: 1914868 HomoloGene: 9130 GeneCards: AASDHPPT
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	106,098,699 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• transferase activity; • GO:0001948, GO:0016582 protein bağlanması; • magnesium ion binding; • metal ion binding; • holo-[acyl-carrier-protein synthase activity];
Hücresel bileşeni	• sitoplazma; • Sitozol; • extracellular exosome;
Biyolojik süreci	• lysine biosynthetic process via aminoadipic acid; • pantothenate metabolic process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	60496
	67618
	ENSG00000149313
	ENSMUSG00000025894
	Q9NRN7
	Q9CQF6
	NM_015423
	NM_026276; NM_001326359
	NP_056238
	NP_001313288; NP_080552
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

L-aminoadipat-semialdehit dehidrojenaz-fosfopanteteinil transferaz, insanlarda AASDHPPT geni tarafından kodlanan bir enzimdir.^[4]^[5]^[6]

Bu gen tarafından kodlanan protein, lizin biyosentetik yolağında alfa-aminoadipat dehidrojenazın etkinleşmesi için gerekli olan Saccharomyces cerevisiae LYS5'e benzer. Maya alfa-aminoadipat dehidrojenazı; alfa-biyosentetik-aminoadipat semialdehiti, alfa-aminoadipata dönüştürür. İnsan genindeki bozuklukların pipekolik asidemiye neden olduğu ileri sürülmüştür.^[6]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149313 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity". J Biol Chem. 278 (35). Aug 2003. ss. 33142-9.
^ "Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene". Mol Genet Metab. 72 (4). Apr 2001. ss. 336-42.
^ ^a ^b "Entrez Gene: AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

Konuyla ilgili yayınlar

"Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). 2005. ss. 1173-8.
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). 2004. ss. 2121-7.
Mammalian Gene Collection Program Team (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26). ss. 16899-16903.
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10). 2001. ss. 1546-60.
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17). 2000. ss. 9543-8.
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5). 2000. ss. 703-13.

Dış bağlantılar

AASDHPPT 10 Mayıs 2017 tarihinde Wayback Machine sitesinde arşivlendi. human gene location in the UCSC Genome Browser [en].
AASDHPPT 10 Mayıs 2017 tarihinde Wayback Machine sitesinde arşivlendi. human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149313 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12815048-4] "Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity". J Biol Chem. 278 (35). Aug 2003. ss. 33142-9.

[pmid11286508-5] "Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene". Mol Genet Metab. 72 (4). Apr 2001. ss. 336-42.

[entrez-6] "Entrez Gene: AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

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