ADAMTS8

ADAMTS8
Tanımlayıcılar
Başka adlar	ADAMTS8
Dış kimlikler	OMIM: 605175 MGI: 1353468 HomoloGene: 5108 GeneCards: ADAMTS8
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	130,428,609 bç
Gen ontolojisi
Moleküler işlevi	• integrin binding; • zinc ion binding; • GO:0070122 peptidase activity; • metalloendopeptidase activity; • heparin binding; • low-affinity phosphate transmembrane transporter activity; • metallopeptidase activity; • hydrolase activity; • metal ion binding;
Hücresel bileşeni	• hücre dışı bölge; • GO:0005578 Hücrelerarası madde; • collagen-containing extracellular matrix;
Biyolojik süreci	• proteolysis; • negative regulation of cell population proliferation; • phosphate ion transmembrane transport;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	11095
	30806
	ENSG00000134917
	ENSMUSG00000031994
	Q9UP79
	P57110
	NM_007037
	NM_013906; NM_001326292
	NP_008968
	NP_038934.2
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Trombospondin motifli bir disintegrin ve metaloproteinaz, üye8, insanların 11. kromozomunda yer alan ADAMTS8 geni tarafından kodlanan bir enzimdir.^[4]^[5]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134917 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33). ss. 23349-57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
^ "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

Ek okuma

Wågsäter D, Björk H, Zhu C, ve diğerleri. (2008). "ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques". Atherosclerosis. 196 (2). ss. 514-22. doi:10.1016/j.atherosclerosis.2007.05.018. PMID 17606262.
Dunn JR, Reed JE, du Plessis DG, ve diğerleri. (2006). "Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours". Br. J. Cancer. 94 (8). ss. 1186-93. doi:10.1038/sj.bjc.6603006. PMC 2361255 . PMID 16570050.
Porter S, Span PN, Sweep FC, ve diğerleri. (2006). "ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma". Int. J. Cancer. 118 (5). ss. 1241-7. doi:10.1002/ijc.21476. PMID 16152618.
Dunn JR, Panutsopulos D, Shaw MW, ve diğerleri. (2004). "METH-2 silencing and promoter hypermethylation in NSCLC". Br. J. Cancer. 91 (6). ss. 1149-54. doi:10.1038/sj.bjc.6602107. PMC 2747718 . PMID 15328519.
Collins-Racie LA, Flannery CR, Zeng W, ve diğerleri. (2005). "ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage". Matrix Biol. 23 (4). ss. 219-30. doi:10.1016/j.matbio.2004.05.004. PMID 15296936.
Ota T, Suzuki Y, Nishikawa T, ve diğerleri. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1). ss. 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, ve diğerleri. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). ss. 16899-903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Georgiadis KE, Hirohata S, Seldin MF, Apte SS (2000). "ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11". Genomics. 62 (2). ss. 312-5. doi:10.1006/geno.1999.6014. PMID 10610729.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134917 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10438512-4] Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33). ss. 23349-57. doi:10.1074/jbc.274.33.23349. PMID 10438512.

[entrez-5] "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

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