ALDH3A1

ALDH3A1
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	3SZA, 3SZB, 4H80, 4L1O, 4L2O
Tanımlayıcılar
Başka adlar	ALDH3A1
Dış kimlikler	OMIM: 100660 MGI: 1353451 HomoloGene: 20175 GeneCards: ALDH3A1
Gen yerleşimi (İnsan)
Krom.	17. Kromozom (insan)
Bitiş	19,748,943 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• benzaldehyde dehydrogenase (NAD+) activity; • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; • GO:0001948, GO:0016582 protein bağlanması; • oxidoreductase activity; • aldehyde dehydrogenase (NAD+) activity; • alcohol dehydrogenase (NADP+) activity; • aldehyde dehydrogenase [NAD(P)+ activity]; • 3-chloroallyl aldehyde dehydrogenase activity;
Hücresel bileşeni	• integral component of membrane; • Hücre zarı; • Endoplazmik retikulum; • extracellular space; • sitoplazma; • Sitozol; • Nükleoplazma; • intracellular membrane-bounded organelle;
Biyolojik süreci	• response to hypoxia; • GO:1904578 response to organic cyclic compound; • response to nutrient; • GO:0010260 hücre yaşlanması; • response to glucocorticoid; • cellular aldehyde metabolic process; • positive regulation of cell population proliferation; • xenobiotic metabolic process; • Metabolizma; • response to cAMP;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	218
	11670
	ENSG00000108602
	ENSMUSG00000019102
	P30838
	P47739
	NM_000691; NM_001135167; NM_001135168; NM_001330150
	NM_001112725; NM_007436; NM_001331112
	NP_000682; NP_001128639; NP_001128640; NP_001317079
	NP_001106196; NP_001318041; NP_031462
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Aldehit dehidrogenaz aile 3, üye A1, insanların 17. kromozomunda yer alan ALDH3A1 geni tarafından kodlanan bir enzimdir.^[4]^[5]^[6]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108602 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hiraoka LR, Hsu L, Hsieh CL (Jul 1995). "Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13". Genomics. 25 (1). ss. 323-5. doi:10.1016/0888-7543(95)80150-K. PMID 7774944.
^ Hsu LC, Chang WC, Shibuya A, Yoshida A (Mar 1992). "Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli". J Biol Chem. 267 (5). ss. 3030-7. doi:10.1016/S0021-9258(19)50690-1. PMID 1737758.
^ "Entrez Gene: ALDH3A1 aldehyde dehydrogenase 3 family, memberA1". 11 Mayıs 2009 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.

Ek okuma

Yoshida A (1993). "Molecular genetics of human aldehyde dehydrogenase". Pharmacogenetics. 2 (4). ss. 139-47. doi:10.1097/00008571-199208000-00001. PMID 1306115.
Vasiliou V, Bairoch A, Tipton KF, Nebert DW (2000). "Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping". Pharmacogenetics. 9 (4). ss. 421-34. PMID 10780262.
Eckey R, Timmann R, Hempel J, ve diğerleri. (1991). "Biochemical, Immunological, and Molecular Characterization of a "High KM" Aldehyde Dehydrogenase". Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology. 284. ss. 43-52. doi:10.1007/978-1-4684-5901-2_6. ISBN 978-1-4684-5903-6. PMID 1905102.
Yin SJ, Vagelopoulos N, Wang SL, Jörnvall H (1991). "Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. 'Variable' and 'constant' enzymes within the alcohol and aldehyde dehydrogenase families". FEBS Lett. 283 (1). ss. 85-8. doi:10.1016/0014-5793(91)80559-L. PMID 2037078.
Santisteban I, Povey S, West LF, ve diğerleri. (1986). "Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3". Ann. Hum. Genet. 49 (Pt 2). ss. 87-100. doi:10.1111/j.1469-1809.1985.tb01680.x. PMID 4073832.
Teng YS (1981). "Stomach aldehyde dehydrogenase: report of a new locus". Hum. Hered. 31 (2). ss. 74-7. doi:10.1159/000153181. PMID 7228061.
Dyck LE (1995). "Polymorphism of a class 3 aldehyde dehydrogenase present in human saliva and in hair roots". Alcohol. Clin. Exp. Res. 19 (2). ss. 420-6. doi:10.1111/j.1530-0277.1995.tb01525.x. PMID 7625577.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2). ss. 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hsu LC, Yoshida A (1993). "Human Stomach Aldehyde Dehydrogenase, ALDH3". Enzymology and Molecular Biology of Carbonyl Metabolism 4. Advances in Experimental Medicine and Biology. 328. ss. 141-52. doi:10.1007/978-1-4615-2904-0_16. ISBN 978-1-4613-6259-3. PMID 8493892.
Rogers GR, Markova NG, De Laurenzi V, ve diğerleri. (1997). "Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH)". Genomics. 39 (2). ss. 127-35. doi:10.1006/geno.1996.4501. PMID 9027499.
Tsukamoto N, Chang C, Yoshida A (1997). "Mutations associated with Sjögren-Larsson syndrome". Ann. Hum. Genet. 61 (Pt 3). ss. 235-42. doi:10.1046/j.1469-1809.1997.6130235.x. PMID 9250352.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ve diğerleri. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2). ss. 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rekha GK, Devaraj VR, Sreerama L, ve diğerleri. (1998). "Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues". Biochem. Pharmacol. 55 (4). ss. 465-74. doi:10.1016/S0006-2952(97)00475-9. PMID 9514081.
Simpson JC, Wellenreuther R, Poustka A, ve diğerleri. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3). ss. 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Rodriguez-Zavala JS, Weiner H (2002). "Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation". Biochemistry. 41 (26). ss. 8229-37. doi:10.1021/bi012081x. PMID 12081471.
Yang M, Coles BF, Delongchamp R, ve diğerleri. (2003). "Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung tissue". Lung Cancer. 38 (1). ss. 15-21. doi:10.1016/S0169-5002(02)00150-2. PMID 12367788.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108602 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7774944-4] Hiraoka LR, Hsu L, Hsieh CL (Jul 1995). "Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13". Genomics. 25 (1). ss. 323-5. doi:10.1016/0888-7543(95)80150-K. PMID 7774944.

[pmid1737758-5] Hsu LC, Chang WC, Shibuya A, Yoshida A (Mar 1992). "Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli". J Biol Chem. 267 (5). ss. 3030-7. doi:10.1016/S0021-9258(19)50690-1. PMID 1737758.

[entrez-6] "Entrez Gene: ALDH3A1 aldehyde dehydrogenase 3 family, memberA1". 11 Mayıs 2009 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.

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