Azapiron

Azapironlar, anksiyolitik, antidepresan ve antipsikotik olarak kullanılan bir ilaç sınıfıdır.^[1]^[2]^[3]^[4] Genellikle seçici serotonin geri alım inhibitörleri (SSRI'lar) gibi diğer antidepresanların yanında destekleyici olarak kullanılırlar.^[5]^[6]^[7]^[8]^[9]^[10]

Azapironlar genel anksiyetede^[11] ve sosyal anksiyete^[12] ve depresyonda SSRI'ların etkisini artırmada fayda göstermiştir.^[13] Panik bozukluk^[14] ve fonksiyonel gastrointestinal bozukluklar için kanıtlar net değildir.^[15]

Yan etkiler

Azapironların yan etkileri baş dönmesi, baş ağrısı, huzursuzluk, mide bulantısı ve ishal olabilir.^[4]^[16]

Azapironların listesi

Azapironlar aşağıdaki ajanları içerir:^[17]

Anksiyolitikler

Alnespiron (S-20,499)
Binospiron (MDL-73,005)
Buspiron (Buspar)
Enilospiron (CERM-3,726)
Eptapiron (F-11,440)
Gepiron (Ariza, Variza)
İpsapiron (TVX-Q-7,821)
Revospiron (BAY-VQ-7,813)
Tandospiron (Sediel)
Zalospiron (WY-47,846)

Antipsikotikler

Perospiron (Lullan)
Tiospiron (BMY-13,859)
Umespiron (KC-9,172)

Kaynakça

^ Eison AS (June 1990). "Azapirones: history of development". Journal of Clinical Psychopharmacology. 10 (3 Suppl): 2S-5S. doi:10.1097/00004714-199006001-00002. PMID 1973936.
^ Cadieux RJ (May 1996). "Azapirones: an alternative to benzodiazepines for anxiety". American Family Physician. 53 (7): 2349-53. PMID 8638511.
^ "Azapirones for generalized anxiety disorder". Cochrane Database of Systematic Reviews. 3 (3): CD006115. 2006. doi:10.1002/14651858.CD006115. PMID 16856115.
^ ^a ^b "Serotonin-1A anxiolytics: an overview". Psychopathology. 22 Suppl 1 (1): 21-6. 1989. doi:10.1159/000284623. PMID 2567039.
^ "Pharmacological treatment of social anxiety disorder". Anxiety Disorders. Modern Trends in Pharmacopsychiatry. 29. 2013. ss. 144-53. doi:10.1159/000351960. ISBN 978-3-318-02463-0. PMID 25225024.
^ "Buspirone augmentation of selective serotonin reuptake inhibitors (SSRIs) in social phobia". Journal of Affective Disorders. 39 (2): 115-21. July 1996. doi:10.1016/0165-0327(96)00030-4. PMID 8827420.
^ "Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression". South African Medical Journal. 87 (4 Suppl): 534-7, 540. April 1997. PMID 9180827.
^ "Buspirone augmentation of antidepressant therapy". Journal of Clinical Psychopharmacology. 18 (6): 465-9. December 1998. doi:10.1097/00004714-199812000-00009. PMID 9864079.
^ "Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study". The Journal of Clinical Psychiatry. 62 (6): 448-52. June 2001. doi:10.4088/JCP.v62n0608. PMID 11465522.
^ "Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: a randomized controlled trial". Psychiatry and Clinical Neurosciences. 57 (2): 183-7. April 2003. doi:10.1046/j.1440-1819.2003.01099.x. PMID 12667165.
^ "Azapirones for generalized anxiety disorder". Reviews (3): CD006115. 2006. doi:10.1002/14651858.CD006115. PMID 16856115.
^ "Pharmacological treatment of social anxiety disorder". Anxiety Disorders. Modern Trends in Pharmacopsychiatry. 29. 20 Eylül 2013. ss. 144-53. doi:10.1159/000351960. ISBN 978-3-318-02463-0. PMID 25225024.
^ Stahl (1 Mayıs 2013). "Serotonergic drugs for depression and beyond". Curr Drug Targets. 14 (5): 578-85. doi:10.2174/1389450111314050007. PMID 23531115.
^ Imai (30 Eylül 2014). "Azapirones versus placebo for panic disorder in adults". The Cochrane Database of Systematic Reviews. 9 (9): CD010828. doi:10.1002/14651858.CD010828.pub2. PMID 25268297.
^ "Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases". J Gastroenterol. 48 (2): 177-81. Feb 2013. doi:10.1007/s00535-012-0726-5. PMC 3698430 . PMID 23254779.
^ "Review of the side-effect profile of buspirone". The American Journal of Medicine. 80 (3B): 17-21. March 1986. doi:10.1016/0002-9343(86)90327-X. PMID 2870641.
^ "The Use of Common Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances: Alphabetical list of stems together with corresponding INNs". 7 Mart 2012 tarihinde kaynağından arşivlendi.

[pmid1973936-1] Eison AS (June 1990). "Azapirones: history of development". Journal of Clinical Psychopharmacology. 10 (3 Suppl): 2S-5S. doi:10.1097/00004714-199006001-00002. PMID 1973936.

[pmid8638511-2] Cadieux RJ (May 1996). "Azapirones: an alternative to benzodiazepines for anxiety". American Family Physician. 53 (7): 2349-53. PMID 8638511.

[pmid16856115-3] "Azapirones for generalized anxiety disorder". Cochrane Database of Systematic Reviews. 3 (3): CD006115. 2006. doi:10.1002/14651858.CD006115. PMID 16856115.

[pmid2567039-4] "Serotonin-1A anxiolytics: an overview". Psychopathology. 22 Suppl 1 (1): 21-6. 1989. doi:10.1159/000284623. PMID 2567039.

[5] "Pharmacological treatment of social anxiety disorder". Anxiety Disorders. Modern Trends in Pharmacopsychiatry. 29. 2013. ss. 144-53. doi:10.1159/000351960. ISBN 978-3-318-02463-0. PMID 25225024.

[pmid8827420-6] "Buspirone augmentation of selective serotonin reuptake inhibitors (SSRIs) in social phobia". Journal of Affective Disorders. 39 (2): 115-21. July 1996. doi:10.1016/0165-0327(96)00030-4. PMID 8827420.

[pmid9180827-7] "Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression". South African Medical Journal. 87 (4 Suppl): 534-7, 540. April 1997. PMID 9180827.

[pmid9864079-8] "Buspirone augmentation of antidepressant therapy". Journal of Clinical Psychopharmacology. 18 (6): 465-9. December 1998. doi:10.1097/00004714-199812000-00009. PMID 9864079.

[pmid11465522-9] "Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study". The Journal of Clinical Psychiatry. 62 (6): 448-52. June 2001. doi:10.4088/JCP.v62n0608. PMID 11465522.

[pmid12667165-10] "Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: a randomized controlled trial". Psychiatry and Clinical Neurosciences. 57 (2): 183-7. April 2003. doi:10.1046/j.1440-1819.2003.01099.x. PMID 12667165.

[11] "Azapirones for generalized anxiety disorder". Reviews (3): CD006115. 2006. doi:10.1002/14651858.CD006115. PMID 16856115.

[12] "Pharmacological treatment of social anxiety disorder". Anxiety Disorders. Modern Trends in Pharmacopsychiatry. 29. 20 Eylül 2013. ss. 144-53. doi:10.1159/000351960. ISBN 978-3-318-02463-0. PMID 25225024.

[13] Stahl (1 Mayıs 2013). "Serotonergic drugs for depression and beyond". Curr Drug Targets. 14 (5): 578-85. doi:10.2174/1389450111314050007. PMID 23531115.

[14] Imai (30 Eylül 2014). "Azapirones versus placebo for panic disorder in adults". The Cochrane Database of Systematic Reviews. 9 (9): CD010828. doi:10.1002/14651858.CD010828.pub2. PMID 25268297.

[15] "Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases". J Gastroenterol. 48 (2): 177-81. Feb 2013. doi:10.1007/s00535-012-0726-5. PMC 3698430 . PMID 23254779.

[pmid2870641-16] "Review of the side-effect profile of buspirone". The American Journal of Medicine. 80 (3B): 17-21. March 1986. doi:10.1016/0002-9343(86)90327-X. PMID 2870641.

[urlThe_Use_of_Common_Stems_in_the_Selection_of_International_Nonproprietary_Names_(INN)_for_Pharmaceutical_Substances:_Alphabetical_list_of_stems_together_with_corresponding_INNs-17] "The Use of Common Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances: Alphabetical list of stems together with corresponding INNs". 7 Mart 2012 tarihinde kaynağından arşivlendi.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]