CD37

CD37
Tanımlayıcılar
Başka adlar	CD37, GP52-40, TSPAN26, CD37 molekülü
Dış kimlikler	OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37
Gen yerleşimi (İnsan)
Krom.	19. Kromozom (insan)
Bitiş	49,343,335 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• GO:0001948, GO:0016582 protein bağlanması;
Hücresel bileşeni	• integral component of membrane; • integral component of plasma membrane; • extracellular exosome; • membrane; • immunological synapse;
Biyolojik süreci	• cell surface receptor signaling pathway;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	951
	12493
	ENSG00000104894
	ENSMUSG00000030798
	P11049
	Q61470
	NM_001040031; NM_001774
	NM_007645; NM_001290802; NM_001290804
	NP_001035120; NP_001765
	NP_001277731; NP_001277733; NP_031671
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Lökosit Antijeni CD37, insanlarda CD37 geni tarafından kodlanan bir proteindir.^[4]^[5]

İşlev

Bu protein, tetraspanin ailesi olarak da bilinen transmembran 4 süperailesinin üyesi olan bu gen tarafından kodlanmıştır Bunun üyelerinin çoğu, dört hidrofobik transmembran etki alanının varlığı aracılığıyla ayırt edici nitelikte olan hücre yüzey proteinleridir. Tetraspaninler, bağışık yanıtların, hücre gelişiminin, etkinleşmenin, büyümenin ve hareketliliğin düzenlenmesinde rol oynayan mediate sinyal iletim olaylarına aracılık etmektedir.^[6]^[7]^[8]^[9] CD37'nin dışa vurumu (ekspresyonu), olgun B hücrelerinin bolluğunda bağışıklık sistemi hücreleriyle kısıtlanmıştır ve T hücreleri ile miyeloid hücrelerde daha düşük ekspresyonu olduğu saptanmıştır. CD37, integrinler ve başka transmembran 4 süperailesi proteinleriyle kompleks yaptığı bilinen hücre yüzey glikoproteinidir. Alternatif uçbirleştirme (alternatif splicing), farklı izoformları kodlayan çoklu transkript türevleri ile sonuçlanır.^[5] CD37, hümoral^[10]^[11] ve hücresel bağışık yanıtlarının ikisini de kontrol eder.^[12]^[13]^[14] Farelerde CD37 eksikliği, B hücreli lenfomaların spontan olarak gelişmesine öncülük eder^[15] ve CD37 negatif lenfomalı hastaların daha kötü bir klinik gidişi bulunmaktadır.^[16]

Ayrıca bakınız

Başkalaşım kümesi

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104894 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6). Mar 1993. ss. 461-5.
^ ^a ^b "Entrez Gene: CD37 CD37 molecule". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology. 5 (2). Şubat 2005. ss. 136-48.
^ "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal. 420 (2). Mayıs 2009. ss. 133-54.
^ "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology. 6 (10). Ekim 2005. ss. 801-11.
^ "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions. 45 (3). 15 Haziran 2017. ss. 741-750.
^ "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLoS Pathogens. 5 (3). Mart 2009. ss. e1000338.
^ "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling. 5 (250). Kasım 2012. ss. ra82.
^ "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology. 20 (15). Ağustos 2000. ss. 5363-9.
^ "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5). Mart 2004. ss. 2953-61.
^ "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1). Ocak 2009. ss. 50-5.
^ "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation. 126 (2). Şubat 2016. ss. 653-66.
^ "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood. 128 (26). Aralık 2016. ss. 3083-3100.

Konuyla ilgili yayınlar

"Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Letters. 288 (1-2). Ağustos 1991. ss. 1-4.
"Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23). Aralık 2001. ss. 4143-51.
"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine. 172 (3). Eylül 1990. s. 1007.
"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine. 169 (4). Nisan 1989. ss. 1497-502.
"The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". Journal of Immunology. 140 (3). Şubat 1988. ss. 905-14.
"Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics. 39 (4). 1994. ss. 249-56.
"Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". International Immunology. 5 (2). Şubat 1993. ss. 209-16.
"Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 (1). Mayıs 1999. ss. 103-11.
"Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". Journal of Clinical Gastroenterology. 29 (1). Temmuz 1999. ss. 63-7.
"Functional expression of transmembrane 4 superfamily molecules on human eosinophils". International Archives of Allergy and Immunology. Cilt 120 Suppl 1. 1999. ss. 38-44.
"A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5). Mart 2004. ss. 2953-61.
"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9). Eylül 2004. ss. 1711-8.
"Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". Journal of Immunology. 178 (1). Ocak 2007. ss. 154-62.
"Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood. 110 (7). Ekim 2007. ss. 2569-77.

Dış bağlantılar

Medical Subject Headings CD37+protein,+human
Human CD37 genome location and CD37 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104894 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8436422-4] "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6). Mar 1993. ss. 461-5.

[entrez-5] "Entrez Gene: CD37 CD37 molecule". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

[6] "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology. 5 (2). Şubat 2005. ss. 136-48.

[7] "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal. 420 (2). Mayıs 2009. ss. 133-54.

[8] "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology. 6 (10). Ekim 2005. ss. 801-11.

[9] "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions. 45 (3). 15 Haziran 2017. ss. 741-750.

[10] "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLoS Pathogens. 5 (3). Mart 2009. ss. e1000338.

[11] "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling. 5 (250). Kasım 2012. ss. ra82.

[12] "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology. 20 (15). Ağustos 2000. ss. 5363-9.

[13] "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5). Mart 2004. ss. 2953-61.

[14] "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1). Ocak 2009. ss. 50-5.

[15] "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation. 126 (2). Şubat 2016. ss. 653-66.

[16] "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood. 128 (26). Aralık 2016. ss. 3083-3100.

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g t d Proteinler: Başkalaşım kümeleri
1-50	CD1 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350