CD59

CD59
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1CDQ, 1CDR, 1CDS, 1ERG, 1ERH, 2J8B, 2OFS, 2UWR, 2UX2, 4BIK
Tanımlayıcılar
Başka adlar	CD59
Dış kimlikler	OMIM: 107271 MGI: 1888996 HomoloGene: 56386 GeneCards: CD59
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	33,736,479 bç
RNA ekspresyonu deseni
	; ; ; ;
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• GO:0001948, GO:0016582 protein bağlanması; • complement binding;
Hücresel bileşeni	• Vezikül; • endoplasmic reticulum membrane; • membrane; • fokal adezyon; • Golgi membrane; • Hücre zarı; • hücre dışı bölge; • cell surface; • compact myelin; • anchored component of external side of plasma membrane; • ER to Golgi transport vesicle membrane; • anchored component of membrane; • Miyolem; • extracellular exosome; • endoplasmic reticulum-Golgi intermediate compartment membrane; • extracellular space; • specific granule membrane; • tertiary granule membrane; • transport vesicle;
Biyolojik süreci	• kan pıhtılaşması; • negative regulation of apoptotic process; • negative regulation of activation of membrane attack complex; • endoplasmic reticulum to Golgi vesicle-mediated transport; • cell surface receptor signaling pathway; • COPII vesicle coating; • positive regulation of T cell proliferation; • regulation of complement activation; • cell activation; • neutrophil degranulation; • regulation of complement-dependent cytotoxicity;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	966
	333883
	ENSG00000085063
	ENSMUSG00000068686
	P13987; Q6FHM9
	P58019
NM_203331; NM_000611; NM_001127223; NM_001127225; NM_001127226;
	NM_001127227; NM_203329; NM_203330
	NM_181858; NM_001368215
NP_000602; NP_001120695; NP_001120697; NP_001120698; NP_001120699;
	NP_976074; NP_976075; NP_976076; NP_000602.1; NP_001120695.1; NP_001120697.1; NP_001120698.1; NP_001120699.1; NP_976074.1; NP_976075.1; NP_976076.1
	NP_862906; NP_001355144
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

CD59 glikoproteini, MAC baskılayıcı protein (MAC-IP), membran reaktif liziz inhibitörü veya protektin olarak da bilinen, insanlarda CD59 geni tarafından ile kodlanan bir proteindir.^[4] LY6/uPAR/alfa-nörotoksin protein ailesine aittir.^[5]

CD59, bir glikofosfatidilinozitol (GPI) tutucusu yoluyla konak hücrelere bağlanır. Kompleman etkinleşmesi, konak hücrelerinde C5b678 çökeltilmesine yol açtığında, CD59, C9'un polimerleşmesini ve membran atak kompleksini oluşturmasını önleyebilir.^[6] Ayrıca, CD59-CD9 kompleksinin endositozu gibi etkin önlemler alması için hücreye sinyal verebilir.^[5]

Kırmızı kan hücreleri üzerinde CD59 dışa vurumunu ve çürüme hızlandırıcı faktörü azaltan GPI'yi etkileyen mutasyonlar paroksismal noktürnal hemoglobinüri ile sonuçlanır.^[7]

HIV, insan sitomegalovirüsü ve vaksinya gibi virüsler, kompleman tarafından lizizlerini önlemek için konak hücre CD59'unu kendi viral zarflarına katar.^[8]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085063 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD59 molecule, complement regulatory protein".
^ ^a ^b "Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review)". International Journal of Oncology. 13 (2). Aug 1998. ss. 305-18.
^ "Defining the CD59-C9 binding interaction". J. Biol. Chem. 281 (37). Eylül 2006. ss. 27398-27404.
^ "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12). 2005. ss. 3699-709.
^ "Cell signals transduced by complement". Mol. Immunol. 41 (6-7). Temmuz 2004. ss. 583-597.

Konuyla ilgili yayınlar

Tandon N, Morgan BP, Weetman AP (1992). "Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells". Immunology. 75 (2). ss. 372-7. PMC 1384722 . PMID 1372592.
Holmes CH, Simpson KL, Okada H, Okada N, Wainwright SD, Purcell DF, Houlihan JM (1992). "Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55)". Eur. J. Immunol. 22 (6). ss. 1579-1585. doi:10.1002/eji.1830220635. PMID 1376264.
Hahn WC, Menu E, Bothwell AL, Sims P, Bierer B (1992). "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59". Science. 256 (5065). ss. 1805-1807. doi:10.1126/science.1377404. PMID 1377404.
Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9". J. Biol. Chem. 267 (19). ss. 13675-80. PMID 1377690.
Petranka JG, Fleenor DE, Sykes K, Kaufman RE, Rosse WF (1992). "Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein". Proc. Natl. Acad. Sci. U.S.A. 89 (17). ss. 7876-7879. doi:10.1073/pnas.89.17.7876. PMC 49817 . PMID 1381503.
Motoyama N, Okada N, Yamashina M, Okada H (1992). "Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene". Eur. J. Immunol. 22 (10). ss. 2669-2673. doi:10.1002/eji.1830221029. PMID 1382994.
Rooney IA, Morgan BP (1992). "Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid". Immunology. 76 (4). ss. 541-7. PMC 1421564 . PMID 1383132.
Tone M, Walsh LA, Waldmann H (1992). "Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation". J. Mol. Biol. 227 (3). ss. 971-976. doi:10.1016/0022-2836(92)90239-G. PMID 1383553.
Philbrick WM, Palfree RG, Maher SE, Bridgett MM, Sirlin S, Bothwell AL (1990). "The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility". Eur. J. Immunol. 20 (1). ss. 87-92. doi:10.1002/eji.1830200113. PMID 1689664.
Sawada R, Ohashi K, Anaguchi H, Okazaki H, Hattori M, Minato N, Naruto M (1990). "Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes". DNA Cell Biol. 9 (3). ss. 213-220. doi:10.1089/dna.1990.9.213. PMID 1692709.
Yamashina M, Ueda E, Kinoshita T, Takami T, Ojima A, Ono H, Tanaka H, Kondo N, Orii T (1990). "Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria". N. Engl. J. Med. 323 (17). ss. 1184-1189. doi:10.1056/NEJM199010253231707. PMID 1699124.
Rooney IA, Morgan BP (1991). "Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins". Immunology. 71 (3). ss. 308-11. PMC 1384423 . PMID 1702747.
Watts MJ, Dankert JR, Morgan EP (1990). "Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids". Biochem. J. 265 (2). ss. 471-7. doi:10.1042/bj2650471. PMC 1136908 . PMID 2302178.
Okada H, Nagami Y, Takahashi K, Okada N, Hideshima T, Takizawa H, Kondo J (1989). "20 KDa homologous restriction factor of complement resembles T cell activating protein". Biochem. Biophys. Res. Commun. 162 (3). ss. 1553-1559. doi:10.1016/0006-291X(89)90852-8. PMID 2475111.
Davies A, Simmons DL, Hale G, Harrison RA, Tighe H, Lachmann PJ, Waldmann H (1989). "CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells". J. Exp. Med. 170 (3). ss. 637-654. doi:10.1084/jem.170.3.637. PMC 2189447 . PMID 2475570.
Sawada R, Ohashi K, Okano K, Hattori M, Minato N, Naruto M (1989). "Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C". Nucleic Acids Res. 17 (16). s. 6728. doi:10.1093/nar/17.16.6728. PMC 318369 . PMID 2476718.
Sugita Y, Tobe T, Oda E, Tomita M, Yasukawa K, Yamaji N, Takemoto T, Furuichi K, Takayama M (1990). "Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement". J. Biochem. 106 (4). ss. 555-7. doi:10.1093/oxfordjournals.jbchem.a122893. PMID 2606909.
Bora NS, Gobleman CL, Atkinson JP, Pepose JS, Kaplan HJ (1994). "Differential expression of the complement regulatory proteins in the human eye". Invest. Ophthalmol. Vis. Sci. 34 (13). ss. 3579-84. PMID 7505007.
Kieffer B, Driscoll PC, Campbell ID, Willis AC, Van Der Merwe PA, Davis SJ (1994). "Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins". Biochemistry. 33 (15). ss. 4471-4482. doi:10.1021/bi00181a006. PMID 7512825.
Kennedy SP, Rollins SA, Burton WV, Sims PJ, Bothwell AL, Squinto SP, Zavoico GB (1994). "Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59". Transplantation. 57 (10). ss. 1494-501. doi:10.1097/00007890-199405000-00017. PMID 7515200.

Dış bağlantılar

Medical Subject Headings CD59+Antigen
Human CD59 24 Haziran 2018 tarihinde Wayback Machine sitesinde arşivlendi. genome location and CD59 28 Nisan 2018 tarihinde Wayback Machine sitesinde arşivlendi. gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085063 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: CD59 molecule, complement regulatory protein".

[pmid9664126-5] "Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review)". International Journal of Oncology. 13 (2). Aug 1998. ss. 305-18.

[pmid16844690-6] "Defining the CD59-C9 binding interaction". J. Biol. Chem. 281 (37). Eylül 2006. ss. 27398-27404.

[parker2005-7] "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12). 2005. ss. 3699-709.

[pmid15219997-8] "Cell signals transduced by complement". Mol. Immunol. 41 (6-7). Temmuz 2004. ss. 583-597.

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g t d Proteinler: Başkalaşım kümeleri
1-50	CD1 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350