CD86

CD86
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1I85, 1NCN
Tanımlayıcılar
Başka adlar	CD86
Dış kimlikler	OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86
Gen yerleşimi (İnsan)
Krom.	3. Kromozom (insan)
Bitiş	122,121,139 bç
RNA ekspresyonu deseni
	; ; ; ;
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• coreceptor activity; • virus receptor activity; • GO:0001948, GO:0016582 protein bağlanması; • signaling receptor binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • signaling receptor activity;
Hücresel bileşeni	• integral component of membrane; • intracellular membrane-bounded organelle; • membrane; • Hücre zarı; • cell surface; • extracellular exosome; • external side of plasma membrane;
Biyolojik süreci	• response to yeast; • adaptive immune response; • response to interferon-gamma; • immune system process; • cell-cell signaling; • T cell costimulation; • GO:0010260 hücre yaşlanması; • myeloid dendritic cell differentiation; • cellular response to cytokine stimulus; • T cell proliferation involved in immune response; • toll-like receptor signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • B cell activation; • response to lipopolysaccharide; • cellular response to metal ion; • negative regulation of T cell anergy; • defense response to virus; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Bağışıklık yanıtı; • positive regulation of T cell proliferation; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • Viral giriş; • GO:0022415 viral process; • toll-like receptor 3 signaling pathway; • cellular response to lipopolysaccharide; • T cell activation; • positive regulation of activated T cell proliferation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of protein kinase B signaling; • GO:0072468 Sinyal transdüksiyonu; • cell surface receptor signaling pathway; • cytokine-mediated signaling pathway; • negative regulation of T cell proliferation;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	942
	12524
	ENSG00000114013
	ENSMUSG00000022901
	P42081
	P42082
	NM_176892; NM_001206924; NM_001206925; NM_006889; NM_175862
	NM_019388
	NP_001193853; NP_001193854; NP_008820; NP_787058; NP_795711
	NP_062261
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Farklılaşma Kümesi 86 (İngilizce: Cluster of Differentiation 86; CD86 ve B7-2 olarak da bilinir), dendritik hücreler, Langerhans hücreleri, makrofajlar, B hücreleri (bellek B hücreleri dahil) ve diğer antijen sunan hücreler üzerinde yapısal olarak eksprese edilen bir proteindir .^[4] CD80 ile birlikte CD86, T hücresi aktivasyonu ve hayatta kalması için gerekli olan kostimülatör sinyalleri sağlar. Bağlanan liganda bağlı olarak CD86, kendi kendini düzenleme ve hücre-hücre birleşmesi için veya düzenlemenin zayıflaması ve hücre-hücre ayrılması için sinyal verebilir.^[5]

CD86 geni, immünoglobulin süper ailesinin bir üyesi olan bir tip I membran proteinini kodlar.^[6] Alternatif birleştirme, farklı izoformları kodlayan iki transkript varyantı ile sonuçlanır. Ek transkript varyantları tarif edilmiştir, ancak bunların tam uzunluktaki sekansları belirlenmemiştir.^[7]

Patolojideki rolü

Hem CD80 hem de CD86'nın rolleri birçok patoloji bağlamında incelenmiştir. Maliyet uyarıcı inhibitörlerin seçici inhibisyonu, bir alerjik pulmoner enflamasyon ve hava yolu hiper-duyarlılığı (AHR) modelinde incelenmiştir.^[8] Staphylococcus aureus'a ilk konak tepkisi, özellikle T hücrelerine dayanan bağışıklık tepkisi, akut pnömoni patogenezinde katkıda bulunan bir faktör olduğundan, CD80 / CD86 yolağının patogenezdeki rolü araştırılmıştır.^[9] Kostimülatör moleküller ayrıca Bronşiyal Astma,^[10] Kanserde Treg^[5] ve immünoterapi bağlamında araştırılmıştır.^[11]

Ayrıca bakınız

Farklılaşma kümesi
CD80
CD28
CTLA-4
CD molekülleri listesi için insan farklılaşma kümelerinin listesi

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114013 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Expression and functional significance of an additional ligand for CTLA-4". Proceedings of the National Academy of Sciences of the United States of America. 90 (23): 11054-8. December 1993. doi:10.1073/pnas.90.23.11054. PMC 47920 . PMID 7504292.
^ ^a ^b "Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?". Cancer Science. 110 (7): 2080-2089. July 2019. doi:10.1111/cas.14069. PMC 6609813 . PMID 31102428.
^ "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". Journal of Immunology. 152 (10): 4929-36. May 1994. PMID 7513726.
^ "Entrez Gene: CD86 CD86 molecule". 2 Kasım 2008 tarihinde kaynağından arşivlendi.
^ "Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation". International Immunology. 10 (11): 1647-55. November 1998. doi:10.1093/intimm/10.11.1647. PMID 9846693.
^ "CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway". Cytokine. 107: 130-136. July 2018. doi:10.1016/j.cyto.2018.01.016. PMC 5916031 . PMID 29402722.
^ "CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma". Allergy. 61 (1): 15-26. January 2006. doi:10.1111/j.1398-9995.2006.01008.x. PMID 16364152.
^ "Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells". Critical Reviews in Immunology. 38 (5): 379-401. 2018. doi:10.1615/CritRevImmunol.2018026790. PMC 6380512 . PMID 30792568.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114013 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Expression and functional significance of an additional ligand for CTLA-4". Proceedings of the National Academy of Sciences of the United States of America. 90 (23): 11054-8. December 1993. doi:10.1073/pnas.90.23.11054. PMC 47920 . PMID 7504292.

[:1-5] "Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?". Cancer Science. 110 (7): 2080-2089. July 2019. doi:10.1111/cas.14069. PMC 6609813 . PMID 31102428.

[pmid75137262-6] "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". Journal of Immunology. 152 (10): 4929-36. May 1994. PMID 7513726.

[7] "Entrez Gene: CD86 CD86 molecule". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

[8] "Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation". International Immunology. 10 (11): 1647-55. November 1998. doi:10.1093/intimm/10.11.1647. PMID 9846693.

[9] "CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway". Cytokine. 107: 130-136. July 2018. doi:10.1016/j.cyto.2018.01.016. PMC 5916031 . PMID 29402722.

[10] "CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma". Allergy. 61 (1): 15-26. January 2006. doi:10.1111/j.1398-9995.2006.01008.x. PMID 16364152.

[11] "Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells". Critical Reviews in Immunology. 38 (5): 379-401. 2018. doi:10.1615/CritRevImmunol.2018026790. PMC 6380512 . PMID 30792568.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

g t d Proteinler: Başkalaşım kümeleri
1-50	CD1 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350